LDN is most commonly used (off‑label) for:Chronic pain conditions like fibromyalgia, myofascial pain, and complex regional pain syndrome (CRPS) .Autoimmune diseases such as multiple sclerosis (MS), Crohn’s disease, ulcerative colitis, Hashimoto’s thyroiditis, and lupus .Neurological and neuroinflammatory conditions like long COVID, ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome), and some forms of neuropathy